" Transhumanism as a whole is a pipe-dream, as it fails to take into account just about everything that actually makes us human, including the nonlocality of consciousness, which they irrationally believe can be uploaded to a cloud-based system and merged with AI, or downloaded into an artificial body construct, such as a synthetic body. " --mercola
I still believe, that this critique ain't the decisive one.
More importantly, we are biological beings with goals programmed through evolution. This means, that neither virtual world nor mechanical body can ever satisfy our existence as much as a simple walk up to a nearest mountain and to feel a fresh air fill your lungs.